15) The genome of PiCV has been sequenced, (16,17) and, on the basis of similarities in their genomes, PiCV is classified, together with psittacine beak and feather disease virus, porcine circovirus types 1 and 2, goose circovirus, canary circovirus, and duck circovirus, as a member of the genus Circovirus in the family Circoviridae.
To date, no reports have described the isolation and propagation of PiCV in cultured cells.
29,30) This has led to speculation that the pathogenicity of PiCV may be similarly affected.
The objective of this study was to evaluate the effect of vaccination of 6-week-old pigeons (an age at which YPDS is usually observed under field conditions) with a commercially available paratyphus vaccine on the progression of PiCV infection and detection of PiCV in cloacal swab, blood, and tissue samples.
The birds were obtained from a loft in which infection with PiCV had been previously diagnosed in young pigeons by results of histologic and electron microscopic examination and PCR testing.
Samples of liver, spleen, intestine, thymus, and bursa were submitted for PiCV PCR analysis, and additional tissue samples were collected and fixed in 10% neutral buffered formalin.
In this study, administration of Colombovac Paratyphus vaccine to 6-week-old pigeons naturally infected with PiCV did not affect the course of the infection nor did it induce signs of young pigeon disease syndrome.
Our experimental approach involved using a PCR assay to investigate the presence of PiCV DNA in tissues from vaccinated and unvaccinated pigeons.
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