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Myr-PKB/Akt-3T3-L1 preadipocytes expressing constitutively active PKB/Akt lacking the pleckstrin homology (PH) domain were provided by S. This amino acid substitution occurs within the pleckstrin homology domain in the amino-terminal region of the protein and is presumed to alter normal B-cell signaling by disrupting protein-protein interactions. 22 PLEKHB1 pleckstrin homology domain containing, family B (evectins), member 1 Hs. |
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