Using pH 4-7 gradient 2-DE, we found that the novel secretory protein PLUNC is differentially expressed among nasal polyps, chronic sinusitis, and normal nasal mucosal tissue.
Sung et al detected upregulation of PLUNC protein expression after bulbectomy in the respiratory epithelium and suggested that PLUNC protein may provide protection against infection after injury.
In our study, both proteomics and immunohistochemical analyses indicated that the highest levels of PLUNC protein expression occurred in chronic sinusitis and the lowest levels in nasal polyps.
8,9) These observations suggest that in response to irritation by infectious agents or chemical factors, the nasal mucosal epithelium, goblet cells, and glandular epithelium will proliferate reactively and produce anti-inflammatory agents, including PLUNC protein, as a defense against the irritant.
PLUNC protein is also an important component of the innate defense system of the nasal mucosa.
In our study of 64 patients who had undergone functional endoscopic sinus surgery to treat nasal polyps or chronic sinusitis, statistical analysis indicated that the intensity of PLUNC protein expression was significantly correlated with postoperative therapeutic efficacy (p < 0.
In our study, we found that therapeutic efficacy was poorer in patients whose levels of PLUNC protein in affected tissue were lower.
PLUNC in human nasallavage fluid: Multiple isoforms that bind to lipopolysaccharide.
Plunc, a member of the secretory gland protein family, is up-regulated in nasal respiratory epithelium after olfactory bulbectomy.
Expression and regulation of PLUNC in human nasal epithelium.