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PXR |
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Pregnane X receptor (PXR), constitutive androstane receptor (CAR), and benzoate X receptor (BXR) define three pharmacologically distinct classes of nuclear receptors. Pregnane X receptor, or PXR, is present in humans but does not recognize or eliminate all toxins as effectively as it does in our diminutive counterparts. Nuclear pregnane X receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification. |
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