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| Acronym | Definition |
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| PRB | Problem | | PRB | Population Reference Bureau (think tank) | | PRB | Powder River Basin (Wyoming) | | PRB | Permeable Reactive Barrier (groundwater treatment technology) | | PRB | Physical Review B (American Physical Society journal of condensed matter and material physics) | | pRb | Retinoblastoma Gene Product | | PRB | Pre-Raphaelite Brotherhood | | PRB | Performance Review Board | | PRB | Project Review Board | | PRB | Program Review Board (DoD MHS) | | PRB | Packet Receive Buffer | | PRB | Renaissance Party du Benin (Benin) | | PRB | Peer Review Board (scholarly organizations) | | PRB | Procurement Review Board | | PRB | Policy Review Board | | PRB | Partai Rakyat Brunei (Brunei People's Party) | | PRB | Physical Resource Block (telecommunications) | | PRB | People's Republic of Bulgaria | | PRB | Personnel Replacement Battalion | | PRB | FCC Private Radio Bureau | | PRB | Procedure Review Board | | PRB | Payload Reference Bench | | PRB | Problem Reporting Bulletin | | PRB | People's Republic of Berkeley (humor) | | PRB | Propeller Bulletin | | PRB | Peoria-Rockford Bus Company | | PRB | Partners in Revitalization and Building | | PRB | Planetary Robotics Building (Carnegie Mellon University) | | PRB | Program Resources Branch (Canada) | | PRB | Publications Review Board (US CIA) | | PRB | Parks and Recreation Board (various locations) | | PRB | Public Reference Branch (US SEC) | | PRB | Pearl River Bridge (Chinese food) | | PRB | Prayer Request Board |
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