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Environmental lead exposure and progressive renal insufficiency. On the basis of these findings, we suggest that in some patients with TGBM nephropathy, progressive renal insufficiency may develop. Such applications may examine the genetic determinants, and cellular and molecular mechanisms, which disrupt normal kidney function; mechanisms of cyst formation and growth; development of experimental model systems; development of markers of disease progression; and the identification of innovative therapeutic interventions and gene targeted strategies to prevent progressive renal insufficiency due to this disorder. |
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