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Recent investigations clearly show that the cellular ascorbate is greatly depleted by exposure to Ni(II) compounds, which results in the inhibition of prolyl hydroxylase activity and activation of HIF-1[alpha] and expression of hypoxia-inducible genes. 4539, a novel small molecule inhibitor of hypoxia-inducible factor (HIF) prolyl hydroxylase (PH) in development for the treatment of tissue damage, improved renal function and achieved today announced that the Company has received a Phase II Small Business Innovation Research (SBIR) grant from the National Heart, Lung, and Blood Institute (NHLBI), part of National Institutes of Health (NIH), which provides continued support for the development of FibroGen hypoxia-inducible factor prolyl hydroxylase ( |
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