Requirement of protein tyrosine kinase
and phosphatase activities for human sperm exocytosis.
Briefly, The templates used for modeling of immunoglobulin domain (pdb ID:2C5D), fibronectin type 3 domain (pdb ID:4PBX) and protein tyrosine kinase
domain (pdb ID:3QUP) was found from RCSB protein data bank  based on high sequences homology and designed individually.
He has contributed to significant translational advances in medicine, including studies providing the rationale for engineering Fc domains to enhance the efficacy of antibody therapeutics in cancer, as well as proof-of-concept studies establishing the clinical utility of JAK and Syk protein tyrosine kinase
inhibitors in T-cell-mediated autoimmunity.
Shalloway, "Regulation of focal adhesion-associated protein tyrosine kinase
by both cellular adhesion and oncogenic transformation," Nature, vol.
The three primary proteins that mediate signal transduction are protein tyrosine kinase
(PTK), protein kinase (PK) and the ras protein.
The ETV6-NTRK3 gene fusion encodes a chimeric protein tyrosine kinase
that transforms NIH3T3 cells.
In APC, volatile anaesthetics appear to mediate their protection in cardiomyocytes by selectively priming sarcolemmal and mitochondrial adenosine-triphosphate-sensitive potassium channels through triggering a complex signal cascade involving protein kinase C, protein tyrosine kinase
, second messenger signal systems such as guanine nucleotide-binding proteins and by the influence on [Ca.
The extent of tyrosine phosphorylation of proteins in response to insulin was determined by assaying protein tyrosine kinase
(PTK) and protein tyrosine phosphatase (PTP) in liver.
Testing is also under way on whether increased levels of an enzyme called protein tyrosine kinase
(PTK) might play a role.
Biochemical characterization of the protein tyrosine kinase
homology domain of the ErbB3 (HER3) receptor protein.
2; ligands for the receptors; nucleic acid sequences that encode the ligands; and methods of stimulating the proliferation and/or differentiation of primitive mammalian hematopoietic stem cells comprising contacting the stem cells with a ligand that binds to a receptor protein tyrosine kinase
expressed in primitive mammalian hematopoietic cells and not expressed in mature hematopoietic cells.
Our studies demonstrate HIV-1 gp120 elicits several different types of signals in macrophages through CXCR4 and CCR5, including calcium elevations, ionic channel activation, non-receptor protein tyrosine kinase
activation, and activation of MAP kinases.