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III]) inhibit insulin-stimulated glucose uptake (ISGU) in 3T3-L1 adipocytes by suppressing the insulin-dependent phosphorylation of protein kinase B (PKB/Akt). Comparison between the microarray and kinase assay results shown in Figure 4 indicates a correlation between protein and gene-level changes in response to arsenic exposure for all genes that were examined in both studies: ERK3, ribosomal S6 kinase 1 (RSK1), cAMP-dependent protein kinase alpha-catalytic subunit (PKAC[alpha]), and protein kinase B (PKB/aktl). |
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