Protocadherin beta 11 and calreticulin expression showed significant decrease (2.
8-fold increase, while expression of cadherin 12 and protocadherin 8 showed significant decrease (1.
Cadherin and protocadherin mutations are reported to be involved in noise-induced hearing loss [13-14,16-17,44].
Digenic inheritance of deafness caused by mutations in genes encoding cadherin 23 and protocadherin 15 in mice and humans.
Calcium-dependent binding of HCN1 channel protein to hair cell stereociliary tip link protein protocadherin 15 CD3.
Gene Product Otoa NM_139310 Otoancorin Cabp2 NM_013878 Calcium binding protein 2 Sod3 NM_011435 Superoxide dismutase 3 Hspb8 NM_030704 Heat shock protein 8 Hsf5 NM_001045527 Heat shock transcription factor member 5 Otof NM_031875 Otoferlin Calca NM_007587 Calcitonin/calcitonin-related polypeptide alpha Pcdha4 NM_007766 Protocadherin alpha 4 Gene Symbol Fold Change p-Value Otoa +3.
2-fold increase in protocadherins alpha 4 and beta 20 expression (Table 2).
1] phase of factor 1 mitotic cell cycle Guanine nucleotide GNB2 signaling pathway binding protein (G protein), beta polypeptide 2 Keratin 13 KRT13 Intermediate filament Keratin 15 KRT15 Intermediate filament Laminin, alpha 3 LAMA3 Cell surface receptor Phosphoinositide- PIK3R1 Phosphatidylinositol 3-kinase, regulatory 3-kinase activity subunit, polypeptide 1 Protocadherin
1 PCDH1 Cell-cell signaling Transducin (beta)-like TBL1XR1 Regulation of 1X-linked receptor 1 transcription Vav 3 oncogene VAV3 Small GTPase-mediated signal transduction V-myc myelocytomatosis MYCL 1 Transcription factor viral oncogene homolog 1 activity Xeroderma pigmentosum, XPA Nucleotide-excision complementation group A repair [iAs.