| Acronym | Definition |
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| POI | Point(s) Of Interest | | POI | Program(s) Of Instruction | | POI | Poisonous (fire diamond warning code) | | POI | Point of Interconnection | | POI | Point of Information | | POI | Proof of Identity | | POI | Point of Impact | | POI | Poor Obfuscation Implementation | | POI | Point Of Interface | | POI | Person of Interest | | POI | Principal Operations Inspector | | POI | Proof of Insurance | | POI | Probability Of Intercept | | POI | Point of Impingement | | POI | Plan Of Instruction | | POI | Points of Interaction | | POI | PURL-Based Object Identifier | | POI | Position of Interest | | POI | Plane of Innovation (Everquest game) | | POI | Perceptual Organization Index | | POI | Program Oral Interpretation (forensics speech) | | POI | Primary Ovarian Insufficiency | | POI | period of interest (US DoD) | | POI | Point of Interception | | POI | Panoramic Optical Imager | | POI | Principles of Instruction | | POI | Products Of Inertia | | POI | Purchase Order Invoice | | POI | Parallel Optical Interface | | POI | Percent of Increase | | POI | Pride On Ice (website) | | POI | Polygons Of Interest | | POI | Purveyor of Innovation (marketing) | | POI | P-mode Oscillations Instrument (Mees Solar Observatory) | | POI | Penguin on Ice | | POI | Planned Operational Interval (US DoD; naval aviation) | | POI | Prior Owner Inscription (book markings) | | POI | Purchase Order Index |
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