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When the researchers compared their 500-gene list to the QTL regions, they found a set of 28 that were both differentially expressed and genetically linked to the observed phenotypes. CollaGenex also currently sells Periostat, which the Company developed as the first pharmaceutical to treat periodontal disease by inhibiting the enzymes that destroy periodontal support tissues and by enhancing bone protein synthesis, and Atridox(R), Atrisorb FreeFlow(R) and Atrisorb-D FreeFlow(R), which are products of QTL, Inc. Once fine mapping has further characterized a previously identified QTL or chromosomal region, candidate nucleotide variants within the locus can be identified. |
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