RAF1V-Raf-1 Murine Leukemia Viral Oncogene Homolog 1
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the commonly mutated PTPN11, SOS1, RAF1, KRAS, BRAF, NRAS, HRAS, MAP2K1, MAP2K2, SHOC2, CBL, SPRED1 genes and less common ones such as LZTR1 (more details about the complete list of genes are provided under request).
Germline gain-of-function mutations in RAF1 cause Noonan syndrome.
Another study has shown that a short hairpin-looped oligodesoxynucleotide, which targets the same 3'-UTR sequence of the v-raf-1 murine leukemia viral oncogene homolog 1 (RAF1) mRNA as miR-125b is able to inhibit protein expression, but not mRNA levels, of RAF1 (76).
At this time the company were also building a Royal Aircraft Factory- designed engine called the RAF1.