the commonly mutated PTPN11, SOS1, RAF1
, KRAS, BRAF, NRAS, HRAS, MAP2K1, MAP2K2, SHOC2, CBL, SPRED1 genes and less common ones such as LZTR1 (more details about the complete list of genes are provided under request).
Germline gain-of-function mutations in RAF1
cause Noonan syndrome.
Another study has shown that a short hairpin-looped oligodesoxynucleotide, which targets the same 3'-UTR sequence of the v-raf-1 murine leukemia viral oncogene homolog 1 (RAF1
) mRNA as miR-125b is able to inhibit protein expression, but not mRNA levels, of RAF1
At this time the company were also building a Royal Aircraft Factory- designed engine called the RAF1