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RANKL

   Also found in: Wikipedia 0.01 sec.
AcronymDefinition
RANKLReceptor Activator of NF-B Ligand


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Cells were cultured in [alpha]-MEM with 10% FBS supplemented with M-CSF (30 ng/mL), RANKL (100 ng/mL), 1% L-glutamine, 1% penicillin/streptomycin, and 1% nonessential amino acids (Gibco).
The DN mechanism enables a broad new opportunity to compete in the rich TNF superfamily of drug targets for autoimmune disease and cancer, which includes BAFF/BLyS, CD40L, RANKL and OX40L.
Dahiyat added, "We are using the Dominant Negative strategy to create new therapeutic candidates and novel intellectual property for several targets in the TNF superfamily, including TNF alpha, RANKL and CD40L.
 
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