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RAR |
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In other words, the RAR response time is significantly reduced. The proposal would also eliminate the use of the traditional RAR by combining it with the issuance of the 30-day letter and limit extensions of time for filing a protest. CYP26 inhibitors are expected to raise endogenous levels of both all-trans and 9-cis retinoic acid in cells expressing the enzyme and thereby activate both RAR and RXR nuclear receptor pathways in a cell- and tissue-specific fashion. |
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