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RXR |
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2], as well as all RAR and RXR isoforms, with exception of RARg, were present in NHNP cells. CYP26 inhibitors are expected to raise endogenous levels of both all-trans and 9-cis retinoic acid in cells expressing the enzyme and thereby activate both RAR and RXR nuclear receptor pathways in a cell- and tissue-specific fashion. RXR levels in the tumor have been shown to be an independent predictor of survival in NSCLC and in other solid tumors. |
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