| Acronym | Definition |
|---|
| RPO | Recruitment Process Outsourcing |
| RPO | Royal Philharmonic Orchestra |
| RPO | Recovery Point Objective (disaster recovery) |
| RPO | Rochester Philharmonic Orchestra |
| RPO | Railway Post Office |
| RPO | Research Process Outsourcing |
| RPO | Representative Poetry Online |
| RPO | Radiation Protection Officer |
| RPO | Regional Planning Organization |
| RPO | Regular Production Option (General Motors) |
| RPO | Remedial Process Optimization (intergovernmental data management) |
| RPO | Right Posterior Oblique |
| RPO | Responsible Pet Owner |
| RPO | Regulating Petty Officer |
| RPO | Really Pissed Off |
| RPO | Retail Postal Outlet (Canada Post) |
| RPO | Reserve Pay Office (US Air Force) |
| RPO | Reasonable and Prudent Operator |
| RPO | Runtime Page Optimizer |
| RPO | Regional Project Office |
| RPO | Record Purpose Only |
| RPO | Religious Petty Officer |
| RPO | Reference Performance Objective (Sprint) |
| RPO | Richmond Philharmonic Orchestra (Richmond, VA) |
| RPO | Rutgers Post Office (Rutgers College) |
| RPO | Revolutions Per Orbit |
| RPO | Recharge Program Office |
| RPO | Reuse Project Officer |
| RPO | Revertive Pulse - Originating |
| RPO | Rolling Pullout (aircraft maneuver) |
| RPO | Regimental Pay Office |
| RPO | Repair Parts Order |
| RPO | Retailer Performance Overview (Vauxhall) |
| RPO | Reliability Programs Office (LANL) |
| RPO | Random Pre-Ordering |
| RPO | Reconfiguration Project Office |
| RPO | Return Purchase Order |
| RPO | Rugby Pays d'Olmes (French rugby team) |
| RPO | Research Protections Office (various schools) |
| RPO | Rzecznik Praw Obywatelskich (Polish: Ombudsman) |