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References in periodicals archive ?
This amazing rational drug design approach has been transformative for sufferers of CML, turning their diagnosis from a certain death sentence to a manageable condition.
Our group's research focuses on the rational drug design of a novel peptidomimetic of the D-Ala-D-Ala peptidoglycan moiety as a bacterial cell wall synthesis inhibitor.
This procedure -- introducing a mutation at a specific site in a gene to alter the structure and shape of a protein -- was revolutionary in the early 1980s, although it is now a standard part of rational drug design.
Perosphere, a company that employs rational drug design to invent proprietary new small molecules for targeted therapeutic indications, has signed a clinical trial contract with Daiichi Sankyo (TYO: 4568),a global pharmaceutical company.
My laboratory and my work are mostly structured around rational drug design, and trying to define how drugs produce their desired and non-desired effects, so as to avoid the second, Pineyro said.
Eldar-Finkelman believes the new compound will be a lead one for treating central nervous system (CNS) disorders, "because it was based on rational drug design.
This work brings together pharmacochemistry researchers who are working on rational drug design to highlight the variety of approaches being employed in this field, such as approaches that start by considering molecular mechanisms of drug action, approaches that focus on the metabolizing enzyme action occurring in the structure of a drug molecule, and approaches that start from the pathobiochemistry and pathophysiology of target diseases.
Cyclacel Limited, a UK-based biopharmaceutical company, has announced progress in its genes-to-drugs CYC400 rational drug design program.
The company recently introduced a new rational drug design methodology, called Quantum Core Technology, to create drugs for various diseases including lead compounds for cancer and viral infections.
The bottom line is that, although the two forms of the enzyme seem very similar, their active sites are subtly different, and this could be a basis for rational drug design.
This strategy utilizes rational drug design for specific molecular targets, such as a receptor or an enzyme thought to be directly involved in a given disease.
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