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Changes in kidney function parallel the changes in cardiac function, with a 60%-80% increase in renal blood flow and a 50% increase in the glomerular filtration rate. Renal changes observed with age include a decrease in mass of the kidneys, a reduction in the size and number of nephrons, a decrease in renal blood flow, and reductions in glomerular filtration rate, renal plasma flow, and tubular function (Mayersohn 1994; O'Mahoney 2000). Decreases in renal blood flow, another side effect of NSAID use, combined with dehydration, can lead to acute renal failure. |
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