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Relationship of hepatic peroxisome proliferation and replicative DNA synthesis to the hepatocarcinogenicity of the peroxisome proliferators di (2-ethylhexl)phthalate and [4-chloro-6-(2,3-xylidino)-2-pyrimidinylthiol]acetic acid (WY-14,643) in rats. 1997); b) that they are refractory to increased markers of replicative DNA synthesis and suppression of apoptosis after exposure to numerous PPAR[alpha] ligands (summarized by Peters et al. Although increased replicative DNA synthesis and cell division have been suggested as the mechanism of peroxisome proliferator-mediated carcinogenesis, persistent increases in hepatocyte proliferation do not occur with DEHP or most hypolipidemic fibrate drugs. |
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