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RAR |
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In what he describes as a molecular fishing expedition, McNamara found that retinoic acid receptors can bind to two clock proteins--Clock and Mop4. Targretin is an RXR-selective ligand that modulates genes essential to maintaining skin homeostasis, without causing the side effects commonly observed with the application of retinoic acid receptor (RAR) selective compounds. RAR-beta-2 normally encodes the protein that serves as the retinoic acid receptor. |
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