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The modern forms of the ribonucleotide reductase probably evolved from some- thing similar to the P. Extensive published research on enzyme active site structures such as those found in hemerythrin, ribonucleotide reductase, methane monooxygenase and many other enzymes reveals the presence of binuclear metallic cores, many of which are carboxylate-bridged (refs. The formulation investigated contains Calando's proprietary delivery technology with an siRNA duplex targeting the M2 subunit of ribonucleotide reductase, a well-established cancer target. |
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