SFRP5Secreted Frizzled-Related Protein 5
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The researchers found that mice lacking SFRP5 were resistant to diet-induced obesity, despite having similar numbers of fat cells as control mice.
In an integrated genetic/epigenetic approach, Serizawa et al (94) prospectively performed mutational screening of a set of 6 genes (FGFR3, PIK3CA, TP53, HRAS, NRAS, and KRAS) and quantitatively assessed promoter methylation status of 11 additional genes (APC, ARF, DBC1, INK4A, RARB, RASSF1A, SFRP1, SFRP2, SFRP4, SFRP5, and WIF1) in NMI-BC tumor biopsy specimens and corresponding urine samples from 118 patients and 33 controls.
Using a very different panel of markers, they found that three genes (SFRP2, SFRP5, and PGR) were differentially methylated in cancer patients.