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SHOX

   Also found in: Wikipedia 0.01 sec.
AcronymDefinition
SHOXShort Stature Homeobox
ShoXScalable Ad Hoc Network Simulator


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Byline: ANI Washington, August 26 (ANI): A team of researchers in Germany have found that not only a gene called SHOX is involved in the development of short stature, but sequences of genetic material on the X and Y chromosome that regulate it are also crucial for growth in children.
Heterozygous carriers of SHOX mutations may be minimally affected or may present with disproportionately short stature, Madelung deformity and other radiographic findings, as in Leri-Weill dyschondrosteosis (LWD).
The higher prevalence and severity of disease in women has been postulated to be due to complementation of SHOX by a Y-specific growth gene, or by the regulatory role exerted on skeletal development by the sex steroids.
 
 
 
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