SHP-1 plays an important role in maintaining tolerance of self-reactive B cells, because conditional B cell-specific deletion of SHP-1 induces activation of self-reactive B cells and production of autoantibodies.
29) SHP-1 activated by CD72 in Sm/RNP-reactive B cells may cause a functionally impaired status distinct from classical anergy.
By specifically recognizing Sm/RNP, CD72 inhibits B cell signaling by activating SHP-1 in Sm/RNP-reactive B cells.
1998) The B cell surface protein CD72 recruits the tyrosine phosphatase SHP-1 upon tyrosine phosphorylation.
2016) Continuous inhibitory signaling by both SHP-1 and SHIP-1 pathways is required to maintain unresponsiveness of anergic B cells.
ITIM in CD72 is then tyrosine-phosphorylated by BCR-associated kinases, such as Lyn, and recruits and activates SHP-1, which in turn inactivates BCR signaling by dephosphorylating various signaling molecules.
We think this is also applicable to diabetic kidney disease, because we observed a similar increase in SHP-1 in the kidneys of diabetic animals," he added.
Additionally, understanding the role that SHP-1 plays in cell survival pathways may shed light on studies of cancer and other diseases, he said.
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, SHP-2, and PTP1B.