SLVLSplenic Lymphoma with Villus Lymphocytes
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8,9,16] Cells of SLVL are smaller than HCL-C cells, have higher nuclear-cytoplasmic ratios,[10] more condensed chromatin,[4] demonstrable nucleoli in 50% of cases, and may be spindled.
Flow cytometry is invaluable in the differential diagnosis of "hairy" lymphocytes because SLVL, HCL-C, HCL-V, and HCL-J often have different immunoprofiles.
We also reviewed the clinical, morphologic, cytochemical, and immunophenotypic criteria helpful in differentiating HCL and SLVL.