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SNRNPSmall Nuclear Ribonucleoprotein
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The researcher says that first is a target-gene binding domain that can be tailored to any gene, while the second domain inhibits mRNA maturation by binding U1 snRNP, a component of the cellular splicing apparatus.
5] Nonstandard abbreviations: SLE, systemic lupus erythematosus; ANA, antinuclear antibodies; IIT, indirect immunofluorescence test; NALIA, nanodot array luminometric immunoassay; snRNP, small nuclear ribonucleoprotein; HRP, horseradish peroxidase; PBS, phosphate-buffered saline; CCD, charge-coupled device.
Esto puede ser explicado de dos maneras: analisis in silico muestran que esta mutacion disminuye la afinidad del ARNm con la U1 snRNP (complejo proteico encargado del corte y empalme).
Clinical usefulness of autoantibodies to U I snRNP proteins in mixed connective tissue disease and systemic lupus erythematosus.