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STAT1Signal Transducer and Activator of Transcription 1 (also seen as STAT-1)
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The STAT1 gene plays a vital role in the body's immune system.
We found that T-bet and STAT1 decreased significantly in both treatment groups (Figure 7A,C; p < 0.
819_822del, 818delT, or 832G>T--all producing premature translation stop, resulting in IFN-[gamma]-R1 proteins truncated in the extracellular domain; lacking intracellular domains, JAK1, and STAT1 binding sites.
Acute alcohol intake induces SOCS1 and S0CS3 and inhibits cytokine-induced STAT1 and STAT3 signaling in human monocytes.
This study aimed to investigate whether IL-28A plays a role in murine myocarditis induced by CVB3, and to explore its possible mechanism involved by determining the expressions of STAT1 and STAT2, Bcl-2, BAX, and Caspase-3 in CVB3-infected heart tissues.
PIAS1 functions by blocking the DNA-binding activity of NF-[kappa]B and STAT1 on gene promoters.
For some transcription factors such as STAT1, AR, HLF, ZEB1, TCF21, ISL1, KLF6, HOXB13, SIM2 and FOXA1, the number of interactions in the metastasis stage decreased dramatically (Table 3); the interaction numbers of other transcription factors, such as ZNF-529, FOXC1, MNX1, and JUNB, increased considerably in the metastasis stage, indicating network rewiring (Table 3).
This cytokine activates both signal transducers and activator of transcription STAT1 and STAT3 through distinct IL-27 receptor subunits and enhances proliferation of naive CD4+T cells.
5] Human genes: PAPPA, pregnancy-associated plasma protein A, pappalysin 1; H19, H19, imprinted maternally expressed transcript (non-protein coding); STAT1, signal transducer and activator of transcription 1, 91kDa; GBP1, guanylate binding protein 1, interferon-inducible; HSD17B1, hydroxysteroid (17-beta) dehydrogenase 1; KRT18, keratin 18; GADD45G, growth arrest and DNA-damage-inducible, gamma.
Tia has STAT1 immune deficiency and tuberculosis-like mycobacterium malmoense.
Tia Pugh, who loves Peppa Pig and the Muppets, has an extremely rare form of immune deficiency called STAT1 deficiency.