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STAT2Signal Transducer and Activator of Transcription 2 (gene)
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The membranes were blocked in 5% BSA for 40 min at room temperature and then incubated individually at 4[degrees]C overnight with primary antibodies, including rabbit polyclonal antibodies against STAT1 (1:1000) and actin (1:2000), and mouse monoclonal antibodies against STAT2 (1:200) (Cell Signaling Technology, Inc.
A Haplotype at STAT2 Introgressed from Neanderthals and Serves as a Candidate of Positive Selection in Papua New Guinea," The American Journal of Human Genetics 91 (2012): 265-74.
The uterine LE/sGE in closest proximity to or adhered to conceptus trophectoderm express these unique genes because IFNT induces expression of IRF2 in uterine LE/sGE to silence expression of ESR1, STAT1, STAT2 and IRF9.
E6 binds to TYK2 preventing binding to the cytoplasmic portion of the IFN receptor inhibiting phosphorylation of TYK2, STAT1, STAT2 impairing JAK STAT activation and therefore inhibiting specifically IFN-[alpha] mediated signalling (64).
STAT2 mediates innate immunity to Dengue virus in the absence of STAT1 via the type I interferon receptor.