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STAT4 |
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The STAT4 SH2 domain binds to IL-12R phosphotyrosines allowing STAT4 to become phosphorylated by the Janus kinases. Transcription factors involved in the regulation of Th1/Th2 responses (a) Effects on Th2 Th1 Transcription factors phenotype phenotype STAT4 + STAT6 + BCL-6 - T-bet - + GATA-3 + - C-maf + NF-Atc + NF-ATp/NF-AT4 - (a) Th, T-helper; STAT, signal transducer and activator of transcription. |
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