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SAHA |
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By inhibiting HDAC, SAHA increases the level of histone acetylation, resulting in increased expression of genes and proteins (such as p27kipl and gelsolin) that are directly implicated in tumor suppression. The most advanced therapeutic candidates such as SAHA and FK228 are already showing promising activity. Later this year, the Company plans to file an application for vorinostat, an investigational compound often referred to in the past as SAHA. |
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