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Related to Salmeterol: Advair, salmeterol xinafoate, Seretide
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References in periodicals archive ?
Because the side chain of salmeterol is anchored at the exosite, the active head portion continually attaches to and detaches from the receptor site.
Our study aimed at evaluation of Accuhaler using drugs fluticasone propionate (100 micrograms) and salmeterol (50 micrograms) in patients of 5-12 age group suffering from moderate persistent asthma.
Salmeterol works by binding to a molecule in the body called the beta-2 receptor, but one in seven asthma sufferers has a genetic mutation in the molecule which makes the treatment less effective.
El xinafoato de salmeterol se disocia en solucion en salmeterol y 1-hidroxi-2-acido naftoico.
Finally, a newer oral NSAID, roflumilast, has been shown to reduce exacerbations in patients with moderate to severe COPD when added to salmeterol or tiotropium (Lancet 2009;374:695-703).
1] were -42[+ or -]3 ml/year for salmeterol alone and fluticasone propionate alone, -39[+ or -]3 ml/year for salmeterol/fluticasone combination, and -55[+ or -]3 ml/ year for placebo (short-acting bronchodilators) (Figure 1).
The Optimal Therapy study (8) compared the addition of placebo, salmeterol or the combination of salmeterol/fluticasone with tiotropium.
The joint session took place nearly 6 years after the Salmeterol Multicenter Asthma Research Trial (SMART), a large, randomized, double-blind study com paring salmeterol inhalation aerosol with placebo in about 26,000 people with asthma over age 12 years (about 12% were 12-18 years old).
The most recent labeling includes a boxed warning stating that products containing salmeterol "may increase the risk of asthma-related death.
Peter Calverley and colleagues carried out a randomised, double-blind trial comparing salmeterol at a dose of 50 [micro]g plus fluticasone propionate at a dose of 500 [micro]g twice daily (combination regimen), administered with a single inhaler, with placebo, salmeterol alone, or fluticasone propionate alone for a period of 3 years.
In March, the Food and Drug Administration (FDA) ruled that the asthma medications fluticasone propionate and salmeterol (Advair) and salmeterol xinafoate (Serevent) must carry the FDA's strongest warning label--a "black box"--alerting users that several deaths have been associated with an ingredient found in these drugs.
The patient had a history of chronic obstructive pulmonary disease with a forced expiratory volume of 820 mL in 1 s (32% of predictive value); he was treated with oral salmeterol, terbutaline, and prednisolone (40 mg/day).