| Acronym | Definition |
|---|
| SIE | Système d'Information sur l'Eau (French: Information System on Water) |
| SIE | Serial Interface Engine |
| SIE | Sierra Health (stock symbol) |
| SIE | Società Italiana di Ergonomia (Italian: Italian Society of Ergonomics) |
| SIE | Self-Imposed Exile |
| SIE | Secrétariat International de l'Eau (French: International Secretariat for Water; UN) |
| SIE | Serviciul de Informatii Externe (Romanian: Intelligence Service for the Exterior) |
| SIE | Società Italiana di Endocrinologia |
| SIE | Staten Island Expressway (Interstate 278; Staten Island, NY) |
| SIE | Spreadsheets in Education (electronic journal) |
| SIE | Surface Integral Equation |
| SIE | Système d'Information Energétique (French: Energy Information System; various locations) |
| SIE | Start Interpretive Execution |
| SIE | Science Information Exchange (Washington, DC, USA) |
| SIE | Structurally Integrated Enclosure |
| SIE | Status Indication Emergency Alignment (SS7) |
| SIE | Système d'Informatique Embarquée (French: Embedded Computing System) |
| SIE | Stanford Institute for the Environment |
| SIE | Standards Improvement Executive |
| SIE | Satellite Imaging Experiment |
| SIE | SOF Information Enterprise |
| SIE | Scattering Integral Equation |
| SIE | System Integration Environment |
| SIE | Sciences, Ingénierie et Environnement (French: Science, Engineering and Environment; University of Paris) |
| SIE | Single Information Environment (Australia) |
| SIE | Self-Initiated Elimination (US Air Force) |
| SIE | Social Issues Executive (Australia) |
| SIE | Special and Inclusive Education (UK) |