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| Acronym | Definition |
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| SPICE | Software Process Improvement and Capability dEtermination (European software development model) | | SPICE | Simulation Program With Integrated Circuit Emphasis | | SPICE | Stanford Program on International and Cross-Cultural Education | | SPICE | Statewide Program for Infection Control and Epidemiology (North Carolina) | | SPICE | Single Pass Inkjet Color Engine | | SPICE | Space Integrated Control Experiment | | SPICE | Society for Promotion of Indian Culture and Ethics | | SPICE | SPectral Imaging of Correlative Events (seismology software) | | SPICE | Scientific Parks and Innovation Centers Experts (Ukraine) | | SPICE | Stanford Program for Integrated Circuit Emulation | | SPICE | Sprint Intelligent Computing Environment | | SPICE | Small Portable Initial Communications Equipment (USAF) | | SPICE | Smart Protocol for Internet Cellular Exchange | | SPICE | Simulation of Polymorphic Interactome in Cancer Etiology (Toronto, Canada) | | SPICE | Social, Physical, Intellectual, Communication, Emotional (child development early learning goals) | | SPICE | Smart, Precise-Impact and Cost-Effective Guidance Kits (munitions) | | SPICE | Situation, Problem, Investigation, Construction, Evaluation (engineering) | | SPICE | Stratospheric Particle Injection for Climate Engineering (geoengineering project; UK) |
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