| Acronym | Definition |
|---|
| SPL | Sound Pressure Level |
| SPL | Special |
| SPL | Spanish Primera Liga (Soccer) |
| SPL | Scottish Premier League |
| SPL | Seattle Public Library |
| SPL | Surgical Planning Laboratory (Boston, MA) |
| SPL | Software Products Library |
| SPL | Seborga Luigini (currency of principality of Seborga) |
| SPL | Structured Product Labeling |
| SPL | Spiral |
| SPL | Senior Patrol Leader (Boy Scouts of America) |
| SPL | Software-PC (Personal Computer) Labeling |
| SPL | Spooler |
| SPL | Schiphol |
| SPL | Samsung Printer Language |
| SPL | Spell Checker (File Name Extension) |
| SPL | Stored Procedure Language |
| SPL | Sha Po Lang (movie title) |
| SPL | Sun Public License (Sun Microsystems) |
| SPL | Système Productif Local (French: Local Productive System) |
| SPL | Service Parts Logistics |
| SPL | Speech Language Pathologist |
| SPL | System Programming Language (computer science) |
| SPL | Scientific Protein Laboratories LLC (Waunakee, WI) |
| SPL | Student Pilot License |
| SPL | Staphage Lysate (Delmont Laboratories, Inc.) |
| SPL | Set Priority Level |
| SPL | Single Premium Life (life insurance) |
| SPL | Simple Programming Language |
| SPL | Signal Processing Language |
| SPL | Superconducting Proton Linac |
| SPL | Spare Parts List |
| SPL | Single Purchase Limit |
| SPL | Scout Patrol Leader |
| SPL | Southern Conference on Programmable Logic |
| SPL | Strokes per Length (swimming) |
| SPL | Second Program Loader (boot loader) |
| SPL | Spare Parts Logistics |
| SPL | Siam Photon Laboratory (Thailand) |
| SPL | Sentence Plan Language |
| SPL | Supplementary Flight Plan |
| SPL | Signal Perfection Limited |
| SPL | Systems and Practices Laboratory |
| SPL | Subjective Poverty Line |
| SPL | School Pupil Leader |
| SPL | Spent Potlinings |
| SPL | Single Point Load (transducer) |
| SPL | Self-Proclaimed Leader |
| SPL | Saint Pachomius Library |
| SPL | Sample/Sampled |
| SPL | Special Processing Laboratory (US NSA) |
| SPL | Split Phase Level |
| SPL | Solar Pumped Laser |
| SPL | Sistina Public License |
| SPL | Second Pressure Level |
| SPL | Service de Police de Laval |
| SPL | Special-Purpose License |
| SPL | Stereo-Photolithography |
| SPL | Spiritual Life Retreat (retreat for churches in MN) |
| SPL | Software Prototyping Laboratory |
| SPL | Span of Loops |
| SPL | Software Pipelining Loop |
| SPL | Six Pack Lions |
| SPL | Spool Parameter List |
| SPL | Senior Practice Leader |
| SPL | Science Photo Library (education resource; UK) |
| SPL | Southwest Public Library (Ohio) |
| SPL | Standard PHP (PHP: Hypertext Preprocessor) Library (computer programming) |
| SPL | Sigourney Public Library (Iowa) |
| SPL | Sunnyvale Public Library (Sunnyvale, CA) |
| SPL | St. Paul's Lutheran (church; various locations) |