| Acronym | Definition |
|---|
| SMB | Small and Medium Business |
| SMB | Server Message Block (protocol) |
| SMB | Staatliche Museen Zu Berlin (national museums in Berlin) |
| SMB | System Management Bus |
| SMB | Små og Mellomstore Bedrifter |
| SMB | Super Mario Brothers (game) |
| SMB | Session Message Block (Samba) |
| SMB | Super Monkey Ball (video game) |
| SMB | Simulated Moving Bed |
| SMB | Seven Mile Beach (Cayman Islands) |
| SMB | Society for Mathematical Biology |
| SMB | Surface Marker Buoy |
| SMB | Steve Miller Band |
| SMB | San Miguel Beer |
| SMB | Sage Master Builder (Sage Software) |
| SMB | Shared Memory Buffer (VME boards) |
| SMB | Soil Microbial Biomass |
| SMB | Screaming Mechanical Brain (band) |
| SMB | Shared Mailbox |
| SMB | Safety Monitoring Board (US NIH) |
| SMB | South Mountain Batholith |
| SMB | Supersonic Molecular Beam |
| SMB | Secret Men's Business |
| SMB | System-Managed Buffering (Virtual Storage Access Method) |
| SMB | School Management Board |
| SMB | San Miguel, Bulacan (Philippines) |
| SMB | Sarap Mag-Beer (Tagalog: San Miguel Beer) |
| SMB | Sarap Maging Barkada (Tagalog: It's fun to have friends) |
| SMB | Shannon-McMillan-Breiman Theorem |
| SMB | Standoff Minefield Breacher |
| SMB | Systems Management Board |
| SMB | Self Mating Beam (aluminum construction) |
| SMB | Space Medicine Branch (Aerospace Medical Association) |
| SMB | Sub-Miniature B Connector |
| SMB | Separate Mechanized Brigade |
| SMB | Sinhalaye Mahasammata Bhumiputra Party (Sri Lanka) |
| SMB | San Miguel Brewery Corp. |
| SMB | Surface Mounted Board |