| Acronym | Definition |
|---|
| SDE | Sub Divisional Engineer |
| SDE | Screen Door Effect (display artifact) |
| SDE | Same Day Edit (videography) |
| SDE | Seller's Discretionary Earnings |
| SDE | Secure Data Exchange |
| SDE | Shallow Dose Equivalent |
| SDE | Senior Developmental Education (Military education) |
| SDE | Service de l'Emploi (French: Employment Service; Switzerland) |
| SDE | Source-Drain Extension |
| SDE | State Department Education |
| SDE | Supplier Development Engineer |
| SDE | Sustainable Development and Environmental Health |
| SDE | Schéma de Développement Economique |
| SDE | Submission and Delivery Entity (ITU-T) |
| SDE | Support Data Extension |
| SDE | Specific Dynamic Effect |
| SDE | Service de l'Etudiant (French: Student Service) |
| SDE | Statement on the Defence Estimates |
| SDE | Signal Display Editor |
| SDE | Software Demonstration Evaluation |
| SDE | Scope Definition Element |
| SDE | Simple Delay Equalization (Hekimian) |
| SDE | Simulated During Exercise |
| SDE | Susquehanna Diversified Engineering |
| SDE | System Development Environment |
| SDE | SOF (Special Operations Forces) Digital Environment |
| SDE | Secretaria de Estado (Portuguese: Secretary of State; various locations) |
| SDE | Senior District Executive |
| SDE | Shared Data Environment |
| SDE | Signal Distribution Equipment |
| SDE | Software Design Engineer |
| SDE | Software Development Engineer |
| SDE | Software Development Environment |
| SDE | Spatial Database Engine |
| SDE | Standard Data Element |
| SDE | Stochastic Differential Equation |
| SDE | Sustainable Development Education |
| SDE | State Designated Entity |
| SDE | Service Development Environment |
| SDE | Special Digital Edition |
| SDE | Small Diesel Engine |
| SDE | Statistical Design of Experiments |
| SDE | Sodium Reactor Experiment |
| SDE | System Design Engineering |
| SDE | Standard Deviation of the Error |
| SDE | Service Delivery Environment (telecommunications) |