| Acronym | Definition |
|---|
| SMD | Science Mission Directorate (NASA) |
| SMD | Surface Mount Device |
| SMD | Standard Microcircuit Drawing |
| SMD | Simian Mobile Disco (band) |
| SMD | Standard Market Design (US Federal Energy Regulatory Commission) |
| SMD | Stanford Microarray Database |
| SMD | Sega Mega Drive (game console) |
| SMD | Single Member District |
| SMD | Southern Maryland |
| SMD | State Medicaid Director |
| SMD | Senile Macular Degeneration |
| SMD | Sauter Mean Diameter |
| SMD | Solder Mask Defined (semiconductor substrate process) |
| SMD | Severe Mood Dysregulation (bipolar disorder) |
| SMD | Soil Machine Dynamics (UK) |
| SMD | Storage Module Device (interface standard for disk drives) |
| SMD | Senior Managing Director |
| SMD | Severely Mentally Disabled |
| SMD | Syndrome Myélodysplasique (French: Myelodysplastic Syndrome) |
| SMD | Storage Module Drive |
| SMD | Sea-Based Midcourse Defense |
| SMD | Suck My Deck (Simian Mobile Disco album) |
| SMD | Standard Military Drawings |
| SMD | Short Message Delivery |
| SMD | Streaming Media Decoder |
| SMD | Speed Measuring Device (as in police radar guns) |
| SMD | Strategic Missile Defense (US DoD) |
| SMD | Skill Matching Database (Australian immigration) |
| SMD | Société de Mèdecine Dentaire |
| SMD | Sea-Based Missile Defense |
| SMD | Strain Measurement Devices Inc (Meriden, Connecticut and Chedburgh, England) |
| SMD | Section de Médecine Dentaire (French: Dental Medicine Section; Switzerland) |
| SMD | State MARS Director |
| SMD | Surface Mounted Diode (electronics) |
| SMD | Solar Magnetic Disturbance |
| SMD | Sigma Mu Delta (pre-medical fraternity) |
| SMD | Syndicat Mixte du Dijonnais (French: Union Meeting of Dijon; France) |
| SMD | Structures and Mechanics Division |
| SMD | Systems Management Division (Intel) |
| SMD | Surface Mean Diameter |
| SMD | Studenten-Mission in Deutschland |
| SMD | Sommaire des Motifs de Décision (French: Summary of Reasons for Decision; Health Canada) |
| SMD | Société Menuiserie Delaplanche (French: Delaplanche Carpenter Company) |
| SMD | Spacelab Mission Development (US NASA) |
| SMD | Sub Mucous Diathermy |
| SMD | Système Métrique Décimal (French: Metric Decimal System) |
| SMD | System Management Daemon (Unix) |
| SMD | Synchronous Message Delivery |
| SMD | Standardized Manufacturing Drawing |
| SMD | Spectrum Matching Detector |
| SMD | Standard Macrobiotic Diet |
| SMD | Service Member Data |
| SMD | Separate Mechanized Division |
| SMD | Ship/Shore Manpower/Manning Document |
| SMD | Systems Management Director/Directorate |
| SMD | Software Management Directorate |
| SMD | Small Munition Dispenser |
| SMD | Smart Metering Device |
| SMD | Shore Maintenance Detachment (US Coast Guard) |
| SMD | Sociedad Madrileña del Dolor (Madrid's Pain Society) |
| SMD | Serrurerie Métallerie Delamaide (French metalworking company) |
| SMD | Small Man's Disease |
| SMD | State Military Department (various locations) |
| SMD | Sheet Music Direct (various locations) |
| SMD | Senior Medical Director (healthcare; various locations) |
| SMD | Stato Maggiore Della Difesa (Italian: General Staff of the Defense) |
| SMD | Small Molecules Department (Rockville, MD) |
| SMD | Sindrome Mielo Displásico (Spanish: Myelo Dysplasic Syndrome) |
| SMD | Smart Mobile Device |
| SMD | School of Medicine and Dentistry (various locations) |