| Acronym | Definition |
|---|
| SMAC | Sid Meier's Alpha Centauri (game) |
| SMAC | Sorbitol MacConkey Agar (clinical microbiology laboratories) |
| SMAC | Second Mitochondria-Derived Activator of Caspases (apoptosis; hematology) |
| SMAC | State Maximum Allowable Cost (pharmacy) |
| SMAC | Servicio de Mediación, Arbitraje y Conciliación |
| SMAC | Spacecraft Maximum Allowable Concentration |
| SMAC | Southern Maryland Athletic Conference |
| SMAC | Southern Michigan Adventure Club |
| SMAC | Smac MAC Address Changer |
| SMAC | Supramolecular Activation Complex |
| SMAC | Student Movement Against Cancer (Scotch Plains-Fanwood High School) |
| SMAC | Shipment Mobility/Accountability Collection |
| SMAC | Sequential Multiple Analyzer Computer |
| SMAC | Shielded Metal Arc Cutting |
| SMAC | Safe Money and Credit (SMAC Vault, Inc.) |
| SMAC | Source Media Access Control (Cisco) |
| SMAC | Scene Matching Area Correlator |
| SMAC | Simulation Model of Automobile Collision |
| SMAC | Suppliers and Manufacturers in Automotive Collaboration |
| SMAC | State Mapping Advisory Council |
| SMAC | Service Center Mainframes Accelerated Consolidation |
| SMAC | Securities Movement and Control (stocks and bonds transactions accounting) |
| SMAC | Suspect Material Action Committee |
| SMAC | Sensor Media Access Control Protocol |
| SMAC | Sunday Morning After Church |
| SMAC | Single Manned Attack Craft (Space Master RPG) |
| SMAC | Supplier Management Awareness and Commitment |
| SMAC | Simple Media Access Control Protocol |
| SMAC | Sit Meum Auxilium Christus (Latin: Christ Be My Help; epigraphy) |
| SMAC | Solow, Minhas, Arrow, Chenery (production function authors) |
| SMAC | Sane's Monthly Algorithms Challenge (computer science) |
| SMAC | Specific, Measurable, Achievable, and Challenging (objectives) |
| SMAC | Sport Martial Arts Championship |
| SMAC | Simple Mastectomy with Axillary Clearance |