| Acronym | Definition |
|---|
| SLE | Systemic Lupus Erythematosus (aka Disseminated Lupus Erythematosus, DLE) |
| SLE | Sara Lee Corporation (stock symbol) |
| SLE | Sierra Leone (ISO Country code) |
| SLE | Student Learning Entitlement |
| SLE | Shore Line East |
| SLE | Slit Lamp Examination (ophthalmology) |
| SLE | Saint Louis Encephalitis (brain-swelling viral infection) |
| SLE | Space Link Extension (CCSDS mechanism for providing distributed access to space link services) |
| SLE | Sober Living Environment (recovery movement) |
| SLE | Single Loss Expectancy |
| SLE | Supported Leading Edge (kites) |
| SLE | Societas Linguistica Europaea (European Association for Linguistics) |
| SLE | Seletar Expressway (Singapore) |
| SLE | Solid Liquid Equilibrium |
| SLE | Structured Liberal Education |
| SLE | St. Lucie Estuary (Florida) |
| SLE | Stressful Life Event (psychiatry) |
| SLE | St. Lawrence Estuary (Quebec, Canada) |
| SLE | South Luzon Expressway (Philippines) |
| SLE | Screen List Editing |
| SLE | Service Logement Etudiant (French: Student Accommodation Service) |
| SLE | Separate Legal Entity |
| SLE | Supervivencia Libre de Enfermedad (Spanish: Disease Free Survival) |
| SLE | Service Life Extension |
| SLE | Southeastern Livestock Exposition |
| SLE | Slackware Linux Essentials |
| SLE | Service Level Expectation |
| SLE | Sharp Laboratories of Europe Limited |
| SLE | Specialised Laboratory Equipment (UK) |
| SLE | Société Lorraine d'Entomologie (French: Lorraine Entomological Society) |
| SLE | Safe Language Extensions |
| SLE | Strength Level Earthquake |
| SLE | Small Library Edition |
| SLE | Shelf Life Extender |
| SLE | Société Loisirs Equipement (French: Recreation Equipment Company) |
| SLE | Synchronous Lateral Excitation |
| SLE | SACLANT Liaison Element |
| SLE | Sports Leisure Entertainment Underwriters |
| SLE | Silent Link Establishment |
| SLE | Strictly Linear Estimation |
| SLE | Software Language and Engineering (International Conference) |
| SLE | SUSE (Gesellschaft für Software-und Systementwicklung) Linux Enterprise (computing) |
| SLE | Supportive Learning Environment (various organizations) |
| SLE | Special Limited Edition (sales) |