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| Acronym | Definition |
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| SOB | Son of a Bitch | | SOB | Shortness of Breath (symptom) | | SOB | South of the Border | | SOB | School Of Business | | SOB | Sexually Oriented Business | | SOB | Scars on Broadway (band) | | SOB | Son of Beast | | SOB | Set Of Books | | SOB | Summary of Benefits | | SOB | Senate Office Building | | SOB | Styles of Beyond (band) | | SOB | South Bend, Indiana (Amtrak code) | | SOB | South Bend, IN (Amtrak) | | SOB | Souls On Board | | SOB | State Office Building | | SOB | Side of Bed | | SOB | Some Other Brand | | SOB | Shrimp On the Barbie | | SOB | Signed-Off-By | | SOB | Small Of Back (holster) | | SOB | Source Of Business | | SOB | Statement of Basis | | SOB | System-On-Board | | SOB | Start Of Block | | SOB | South Of Border | | SOB | Start Of Business | | SOB | Sons of Butcher (band) | | SOB | Son of the Boss | | SOB | Sailor on Board | | SOB | Share of Business | | SOB | Signs Of Betrayal (rock band) | | SOB | Sick of Bush | | SoB | Seal of Blood (gaming, World of Warcraft) | | SOB | Silly Old Bear | | SOB | Silly Old Bugger (British) | | SOB | Socially Offensive Behavior (TV show) | | SOB | Smelling Of Booze | | SOB | Super Oralloy Bomb | | SOB | Seaford-Oyster Bay Expressway (Long Island, New York) | | SOB | South Orange Blossom (Florida street name) | | SOB | Society of Orpheus and Bacchus (Yale University a capella group) | | SOB | Sweet Old Bob | | SOB | Son of Bazerk (hip hop) | | SOB | Star Onion Brigade (game, Final Fantasy XI) | | SOB | Short(ness) of Breath (medical) | | SOB | South Oyster Bay (New York) | | SOB | Slide Over Baby | | SOB | Same Ocean Buddy (Scuba) | | SOB | Silly Old Bastard (Australian) | | SoB | Saecula Omnimodus Bellum | | SOB | Space Order of Battle | | SOB | Statement of Boredom | | SOB | Sons of Batman | | SOB | Balaton - Sármellék Hungary (Airport Code) | | SOB | Société Ornithologique du Boulonnais (French: Ornithological Society of Boulogne; France) | | SOB | Save Our Businesses (Florida tax proposal) | | SOB | Sell on Bottoms | | SOB | Sample Of Behavior | | SOB | Special Operations Base | | SOB | Standard Operational Bullstuff (polite form) | | SOB | Stupid Old Bastard | | SOB | Standard Operating Business | | SOB | Satan's Own Breedwork :-) | | SOB | Service Organisation Bureau (French: Service Organization Office) | | SOB | Stop on Barrier | | SOB | Straight Offset Binary | | SOB | State Operations Budget | | SOB | Société Odontologique de Brest (French: Brest Dental Company; France) | | SOB | Sex Offenders Beware! (website) | | SOB | South Omaha Boy | | SOB | Smart Operating Business | | SOB | Soggy on Bottom | | SOB | Sense of Belonging | | SOB | Sexual Offences Bill |
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