| Acronym | Definition |
|---|
| SPF | Sun Protection Factor (sun block rating) |
| SPF | Sender Policy Framework (antispam initiative) |
| SPF | Service Public Fédéral (Belgium) |
| SPF | Shortest Path First |
| SPF | Specific Pathogen Free |
| SPF | Singapore Police Force |
| SPF | Strategic Prevention Framework (US federal grant program) |
| SPF | Sygate Personal Firewall |
| SPF | Single Point of Failure |
| SPF | Sender Permitted From (email; now Sender Policy Framework) |
| SPF | Secours Populaire Français |
| SPF | Sasakawa Peace Foundation (Japan) |
| SPF | Spruce Pine Fir |
| SPF | South Pacific Forum |
| SPF | Skin Protection Factor |
| SPF | Superplastic Forming (metallurgy) |
| SPF | Servicio Penitenciario Federal (Spanish; Argentina) |
| SPF | Spray-applied Polyurethane Foam |
| SPF | Single Point Failure |
| SPF | Standard Pacific Corporation (stock symbol) |
| SPF | System Productivity Facility (system used in TSO to create and edit data) |
| SPF | Standard Project Flood |
| SPF | Servicio Público Federal (Mexico) |
| SPF | Swiss Peace Foundation |
| SPF | Structured Programming Facility |
| SPF | Super Frame (ITU-T) |
| SPF | SmartPlant Foundation (Intergraph) |
| SPF | System Programming Facility |
| SPF | Space Power Facility (NASA) |
| SPF | Stile Project Forum |
| SPF | Software Production Facility (NASA) |
| SPF | Slide Presentation File (EnerGraphics file extension) |
| SPF | Skagitonians to Preserve Farmland (Mount Vernon, WA) |
| SPF | Standard Parasitic Format |
| SPF | Sold Pending Funds |
| SPF | Subscriber Plant Factor |
| SPF | Sodium Process Facility |
| SPF | Special Purpose Force |
| SPF | Special Programs File |
| SPF | Synthetic Phase Fraction |
| SPF | Security Police Flight |
| SPF | Signal Processing Facility |
| SPF | Strategic Projection Force |
| SPF | SIDPERS Personnel File |
| SPF | Science Policy Foundation (United Kingdom) |
| SPF | Specialist Portfolio (New York Stock Exchange) |
| SPF | Sensor Fusion Post |
| SPF | Shipper Paid Forwarding (US Postal Service program for payments) |
| SPF | S&P Food Industries (Malaysia) |
| SPF | Site Population Factor |
| SPF | Stair Pressurization Fan (mechanical services) |
| SPF | Stealthy Packet Filter (Firewall) |
| SPF | Single Point of Filing |
| SPF | Scientific Primates Filipinas, Inc |
| SPF | Single Project Funded |
| SPF | Special Performance File |
| SPF | Spare Parts File |
| SPF | Special Function Memory |
| SPF | Signal on Protection Fiber |
| SPF | Standard Plume Flowfield code |
| SPF | Sabaragamu Peoples' Foundation (Sri Lanka) |