| Acronym | Definition |
|---|
| SME | System Management Entity |
| SME | Small and Medium-Sized Enterprise |
| SME | Small and Medium Enterprises |
| SME | Society for Mining, Metallurgy, and Exploration |
| SME | Système de Management Environnemental (French: Environmental Management System) |
| SME | Sistema Monetario Europeo (Italian) |
| SME | Système Monétaire Européen (French: European monetary system) |
| SME | Secure Mobile Environment |
| SME | Society of Mining Engineers |
| SME | Santé Mentale Europe (French: Mental Health Europe) |
| Sme | Sinorhizobium Meliloti |
| SME | Shawnee Mission East |
| SME | Significant Military Equipment |
| SME | Shape Memory Effect (engineering) |
| SME | Shimoga (Indian town railway code) |
| SME | Solar Mesosphere Explorer |
| SME | Short Message Entity |
| SME | Soy Methyl Ester (biodiesel) |
| SME | Stato Maggiore dell'Esercito (Italian: Army General Staff) |
| SME | Spatial Modeling Environment |
| SME | Standard Model Extension (physics) |
| SME | Senior Management Executive |
| SME | Soil and Materials Engineers, Inc (Plymouth, MI) |
| SME | Sales & Marketing Executives International |
| SME | Solutions Middle East |
| SME | Square Meter Equivalent (textile trade) |
| SME | Sloppy Meateaters (band) |
| SME | Sun Microelectronics (Sun Microsystems, Inc.) |
| SME | Squadron Medical Element |
| SME | Saami, Northern (Norwegian ISO Language Code) |
| SME | Sports Media Entertainment (broadcast outlet) |
| SME | School of Materials Engineering |
| SME | Security Message Exchange |
| SME | Synchronous Modem Eliminator |
| SME | Semaine Mondiale de l'Entrepreneuriat (French: Global Week of Entrepreneurship) |
| SME | Seine-Maritime Expansion (est. 1968) |
| SME | Signaling Message Encryption |
| SME | Society of Military Engineers |
| SME | Sausage McMuffin with Egg (McDonalds) |
| SME | State Machine Editor |
| SME | Surface Mobile Equipment |
| SME | Republic of Surinam (international auto identification) |
| SME | Software Management for Executives (training course) |
| SME | Systems Maintenance Engineer |
| SME | Services de Migration et Etrangers (French: Migration and Foreigners Services; Angola) |
| SME | Static Model Exchange |
| SME | Sales Management Engineer |
| SME | Stratégie Marine Européenne (French: EU Marine Strategy) |
| SME | Special Minister of the Eucharist |
| SME | Session Management Engine (software development and testing) |
| SME | Selector Mark Enable |
| SME | Société Métallurgique d'Epernay (French: Metallurgical Society of Epernay; France) |
| SME | Solid-Metal Embrittlement |
| SME | Surface Movement Element |
| SME | Shape Metal Effect |
| SME | Specialized Market Expert |
| SME | Small Management Element |
| SME | Supply Management Executive/Expert |
| SME | Submucosal Extension |
| SME | Submucosal Mass Effect |
| SME | Sharp Microelectronics Europe (Hamburg, Germany) |
| SME | Sony Music Entertainment |
| SME | Science-Mathematics Education (various schools) |
| SME | Service Management Europe (UK) |
| SME | Service Management Enterprise (software) |
| SME | Senior Mechanical Engineer |
| SME | Subject Matter Expertise |
| SME | School of Military Engineering |
| SME | Subject Matter Expert |
| SME | Society of Manufacturing Engineers |