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| Acronym | Definition |
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| SPB | Spb Software House | | SPB | State Personnel Board | | SPB | Saint Petersburg | | SPB | Southern Pine Beetle | | SPB | Spindle Pole Body (biology, biochemistry) | | SPB | Sea Plane Base | | SPB | Special Pathogens Branch (Centers for Disease Control) | | SPB | Schynige Platte Bahn (German; Swiss mountain railway) | | SPB | Survivor Benefit Plan (US DoD) | | SPB | Simple Payback (engineering economics) | | SPB | Security Policy Board | | SPB | Summative Project Brief | | SPB | State Parole Board (New Jersey) | | SPB | Sociedade Portuguesa de Bioquímica (Portuguese Society of Biochemistry) | | SPB | Secret Policeman's Ball | | SPB | St Thomas Island, VI, USA - Seaplane Base (Airport Code) | | SPB | Scénario Paintball (French: Scenario Paintball; online paintball forum) | | SPB | SP Balasubramanyam (Indian singer) | | SPB | Special Projects Branch (National Institutes of Health) | | SPB | San Pawl il-Bahar (postal locality, Malta) | | SPB | Strategic Planning Board | | SPB | Strategic Planning and Budget (Office) | | SPB | Sphere Packing Bound | | SPB | Sripathi Panditaradhyula Balasubramaniam (Indian singer) | | SPB | Selling Price Breakdown (OEM industry) | | SPB | Senior Professional Band (General Electric) | | SPB | Shanghai Price Bureau | | SPB | Shifted Polynomial Basis | | SPB | Single-Point Background | | SPB | Shanghai Sports Bureau | | SPB | Ship Protected Barrier (US Navy) | | SPB | Special Purpose Bodies (various organizations) | | SPB | Super Paint Brawl (community forum) | | SPB | Silicon Package Board | | SPB | Split Pillow Block (engineering) | | SPB | Semi Prismatic type B (LNG storage tank) |
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