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An in vitro study employing human peripheral blood basophils demonstrated that forskolin, functioning as a phosphodiesterase inhibitor, significantly suppressed the release of cytokines IL-4 and IL-13 that are secreted by the basophils after the cross-linking of cell surface immunoglobulins. Immunophenotyping of these tumor cells reveals that they express surface immunoglobulins and B-cell antigens but lack CD5, CD10, and CD23. ] B cells with surface immunoglobulins of only [Lambda] type (ie, evidence of clonal excess, consistent with a diagnosis of B-CLL). |
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