| Acronym | Definition |
|---|
| SPE | Society of Petroleum Engineers |
| SPE | Solid Phase Extraction |
| SPE | Sony Pictures Entertainment |
| SPE | Special Purpose Entity |
| SPE | Software Performance Engineering |
| SPE | Synergistic Processor Element |
| SPE | Siemens Professional Education (formerly Siemens-Berufsausbildung) |
| SPE | Synchronous Payload Envelope |
| SPE | Society of Professional Engineers |
| SPE | Society for Photographic Education |
| SPE | Synergistic Processing Element |
| SPE | Solid Polymer Electrolyte |
| SPE | Serum Protein Electrophoresis |
| SPE | Sigma Phi Epsilon |
| SPE | Streptococcal Pyrogenic Exotoxin |
| SPE | Solar Particle Event |
| SPE | Solid Phase Epitaxy |
| SPE | Service Processing Element (Cisco) |
| SPE | Semiconductor Production Equipment |
| SPE | Subgame Perfect Equilibrium (game theory) |
| SPE | Senior Procurement Executive |
| SPE | Society of Plastics Engineers, Inc. |
| SPE | Solar Proton Event |
| SPE | Software Product Engineering |
| SPE | Servicios Públicos de Empleo (Spanish) |
| SPE | Supervisory Patent Examiner |
| SPE | Symbolic Programming Environment |
| SPE | Sales Per Employee |
| SPE | Solid Particle Erosion |
| SPE | Special Purpose Equipment |
| SPE | Société Coopérative de Production d'Electricité (Belgium electric company) |
| SPE | Solid Phase Epitaxial Regrowth |
| SPE | Secondary Particulate Emissions |
| SPE | Software Product Evaluation |
| SPE | SONET Payload Envelope |
| SPE | Sauber Petronas Engineering |
| SPE | Synergistic Processing Engine |
| SPE | Society for Pure English |
| SPE | subtracting pore effect |
| SPE | Soy Phytoestrogen |
| SPE | Satellite Precipitation Estimate |
| SPE | Small Program Enhancement (IBM) |
| SPE | Spacecraft Power Electronics |
| SPE | Sensor Processing Electronics |
| SPE | Services Protected Evacuation |
| SPE | Spherical Probable Error |
| SPE | Systems Performance Effectiveness |
| SPE | Service Platform Engineering |
| SPE | Swedish Penis Enlarger (Austin Powers) |
| SPE | Software Product Expert |
| SPE | Stored Program Element (USAF SACCS 465L EDTCC) |
| SPE | Startup Phase Error |
| SPE | Sulfur Polymer Encapsulation |
| SPE | Sum of Predicted Error |
| SPE | South Pit Extension (Project; Australia) |
| SPE | SIPRnet Premise Equipment |