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On the contrary, the patients with large-sized mitral valve prosthesis achieved a decrease in systolic pulmonary artery pressure (PAP) and a non significant decrease in cardiac mass index, but had worse LV systolic and Following on the statistically significant 40% reduction in systolic pulmonary artery pressure (SPAP) seen in EPIX's Phase 2a clinical trial of its highly selective 5-HT2B antagonist PRX-08066 in patients with pulmonary hypertension (PH) associated with chronic obstructive pulmonary disease (COPD), EPIX expects to initiate a Phase 2b right-heart catheter study in the first quarter of 2008. Efficacy was measured by the effect of PRX-08066 compared to placebo on systolic pulmonary artery pressure (SPAP) and included 62 evaluable patients who completed the double-blind portion of the study. |
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