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Thioredoxin reductase is an essential enzyme important in maintaining cellular thiol-redox homeostasis and defense against oxidant stress and also mediates important cocytokine activities via its substrate thioredoxin, which can act as a potent T-cell growth factor (21-30). NF-AT controls T-cell activation by regulating the transcription of the Interleukin-2 gene, a critical T-cell growth factor. IL-2, originally called T-cell growth factor, is produced in the body by T-cells and has potent effects on the maturation and proliferation of a number of cell types, including T-cell, B-cells and natural killer cells. |
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