Keywords: Acute T1DM
, American Diabetes Association (ADA), fulminant T1DM
, International Society for Paediatric and Adolescent Diabetes (ISPAD), LADA, Japan Diabetes Society (JDS), T1DM
, slowly progressive T1DM
Children and young adolescent with T1DM
are at increased risk of various psychosocial problems especially depression.
Two H LA class II haplotype, DR4-DQ8 and DR3-DQ2 are present in about 90% of children with T1DM
Insulin therapy is the primary approach for pharmacological management, particularly in patients with T1DM
tanisi alan tum olgularin 122'sinde (%43,1) DKA saptandi.
The main pathology in T1DM
is the destruction of pancreatic beta cells.
A retrospective cohort study in Brazil reported that patients with T1DM
and T2DM did not achieve targets for HbA1c [24,25].
This is particularly important in T1DM
, where a higher proportion of patients are female.
sup] In addition, the worldwide prevalence of T1DM
keeps increasing in recent years.
Apoptosis is a cause of absolute [beta]-cell deficiency in T1DM
and relative [beta]-cell deficiency in T2DM.
Also, agrees with (Bener et al,2009) who found that vitamin D deficiency was considerably higher in T1DM
Another study showed that TT genotype (Val/Val) was most common in both T1DM
and T2DM patients; CT genotype was common in healthy subjects whereas the CC genotype (Ala/Ala) was rare in all groups (69).