Additionally, TBTC at concentrations [greater than or equal to] 20 nM significantly decreased oxygen consumption in Am cybrids when compared with untreated cybrids (Figure 1B).
We found that at concentrations [greater than or equal to] 15 nM, TBTC significantly decreased ATP levels in Om and Am cybrids when compared with untreated cybrids (Figure 2).
In a previous study, MIMP was diminished in mouse thymocytes treated with 10 nM TBTC (Sharma and Kumar 2014).
In a previous study, 10-nM concentrations of TBTC increased [H.
A previous report showed that 100 nM TBTC decreased IDH activity in human embryonic carcinoma NT2/D1 cells.
All of these results support CV as the target of TBTC (von Ballmoos et al.
TBTC is a potent algicide and molluscicide that was used in marine antifouling ship paints (Grun 2014).
The phenotypic differences provoked by TBTC between cybrids from the same nuclear genetic background suggest that mtDNA is the responsible factor.
Of the 1,004 HIV-negative participants in TBTC Study 22, there were 8 instances of treatment failure and 61 cases of relapse.
Asian-Pacific Islanders were not at increased risk for relapse in the entire TBTC Study 22 cohort or in this nested case-control analysis (OR 0.
Adjustment for the clinical, radiographic, and microbiologic risk factors for treatment failure and relapse and for treatment assignment in TBTC Study 22 had little effect on the association between active disease caused by a Beijing strain and the risk for relapse.
One clear bias in the study population is that TBTC Study 22 was limited to patients with drug-susceptible TB.